Related Experiment Videos
High-grade lymphoma after azathioprine treatment for Vogt-Kaganayi-Harada syndrome
Charmaine Hon1, Shu-Leong Ho, Edmond S K Ma
1Department of Ophthalmology, Queen Mary Hospital, the University of Hong Kong, Hong Kong.
Abstract:
Vogt-Kaganayi-Harada (VKH) syndrome is a rare autoimmune disease characterized by panuveitis, neuropathy and aseptic meningitis. Most patients require long-term treatment with steroids and immunosuppressants. Patients may develop concurrent autoimmune diseases, especially endocrinopathies. Secondary malignancies are rare associations. We report a Chinese man with VKH syndrome presenting with multiple cranial nerve palsy and bilateral pan-uveitis, who developed disseminated high-grade B cell lymphoma after 3-year treatment with azathioprine. This is the first report of systemic non-Hodgkin lymphoma in patients with VKH syndrome. The carcinogenic properties of azathioprine on an abnormally expanded but non-clonal lymphoid system may play a role in the pathogenesis.
Related Concept Videos
Treatment Resistant Cancers
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Treatment Resistent Cancers
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...