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Related Experiment Videos

Voriconazole-induced musical hallucinations.

A K Agrawal1, L K Sherman

  • 1Baylor College of Medicine, Houston, Texas, USA.

Infection
|December 31, 2004
PubMed
Summary

Voriconazole, an antifungal, can cause rare musical hallucinations. A patient experienced these auditory hallucinations, which resolved after discontinuing the medication.

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Area of Science:

  • Pharmacology
  • Neurology
  • Mycology

Background:

  • Voriconazole (Vfend) is a widely used second-generation azole antifungal.
  • It is prescribed for invasive aspergillosis and febrile neutropenia.
  • Voriconazole typically has a mild side effect profile, with visual disturbances being most common.

Observation:

  • A case study of a 78-year-old man undergoing chemotherapy for acute myelogenous leukemia (AML).
  • The patient developed auditory hallucinations, specifically hearing Christmas music, on the second day of voriconazole therapy.
  • Psychiatric evaluation revealed no other significant findings.

Findings:

  • Discontinuation of voriconazole led to a decrease in hallucination intensity by day two and complete cessation by day three.
  • A comprehensive literature search, including drug trial data, found no previous reports of auditory hallucinations associated with voriconazole.
  • Musical hallucinations are often linked to temporal lobe issues and can have religious or patriotic themes.

Implications:

  • This case highlights a rare potential side effect of voriconazole, specifically musical auditory hallucinations.
  • It suggests that clinicians should consider voriconazole as a potential cause of musical hallucinations in patients.
  • Further research may be warranted to understand the neurobiological mechanisms underlying this rare adverse drug reaction.

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