Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Profiling gene expression in kidney development.

Larry T Patterson1, S Steven Potter

  • 1Division of Nephrology, Children's Hospital Research Foundation, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

Nephron. Experimental Nephrology
|January 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Effectiveness of Antihypertensive Medications in Children With Chronic Kidney Disease.

JAMA pediatrics·2026
Same author

Proximal Tubule Cells Contribute to the Thin Descending Limb of the Loop of Henle during Mouse Kidney Development.

Journal of the American Society of Nephrology : JASN·2025
Same author

Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development.

bioRxiv : the preprint server for biology·2025
Same author

Intercellular mRNA transfer alters the human pluripotent stem cell state.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State.

bioRxiv : the preprint server for biology·2024
Same author

Single-Cell Transcriptomic Profiling Identifies Molecular Phenotypes of Newborn Human Lung Cells.

Genes·2024
Same journal

Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats.

Nephron. Experimental nephrology·2015
Same journal

Polyuria in Hantavirus Infection Reflects Disease Severity and Is Associated with Prolonged Hospital Stay: A Systematic Analysis of 335 Patients from Southern Germany.

Nephron. Experimental nephrology·2014
Same journal

Stimulation of Cyclooxygenase 2 Expression in Rat Peritoneal Mesothelial Cells.

Nephron. Experimental nephrology·2014
Same journal

Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers.

Nephron. Experimental nephrology·2014
Same journal

Wnt5a is necessary for normal kidney development in zebrafish and mice.

Nephron. Experimental nephrology·2014
Same journal

Protective effects of relaxin against cisplatin-induced nephrotoxicity in rats.

Nephron. Experimental nephrology·2014
See all related articles

Microarrays enable rapid gene expression analysis, revolutionizing kidney development studies. This technology reveals thousands of genes, identifying new pathways crucial for kidney organogenesis and providing a baseline for developmental research.

Area of Science:

  • Developmental Biology
  • Genomics
  • Molecular Biology

Background:

  • Microarray technology allows for high-throughput gene expression profiling.
  • Understanding gene expression dynamics is crucial for studying organogenesis.
  • Kidney development involves complex genetic regulation.

Purpose of the Study:

  • To investigate genome-wide gene expression patterns during kidney development.
  • To identify novel genes and pathways involved in kidney organogenesis.
  • To establish a molecular baseline for studying kidney developmental abnormalities.

Main Methods:

  • Utilized microarray technology for genome-wide expression analysis.
  • Analyzed gene expression in developing rat, mouse, and human kidneys.

Related Experiment Videos

  • Combined microarrays with microdissection for cell-type-specific analysis.

    • Main Results:

    • Identified thousands of expressed genes in the developing kidney.
    • Observed hundreds of genes with significant expression changes over developmental time.
    • Discovered novel genes and pathways implicated in kidney organogenesis.

    Conclusions:

    • Microarrays are a powerful tool for studying kidney development.
    • Gene expression profiling provides insights into developmental processes and identifies new molecular players.
    • The generated molecular portrait serves as a reference for studying kidney mutants.