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Updated: Jul 22, 2026
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma
Sung-Yon Choi1, Myung Hyun Sohn, Hye-Yung Yum
1Department of Pediatrics and Allergy Institute, Yonsei University College of Medicine, Seoul, Korea.
Pediatric Pulmonology
|January 6, 2005
Summary
In asthmatic children, sensitization to Dermatophagoides (Der p. and Der f.) allergens is linked to reduced lung function. German cockroach and Alternaria allergens showed no significant impact on pulmonary function in this study.
Area of Science:
- Pediatric Allergy and Immunology
- Pulmonary Medicine
- Immunology
Background:
- Aeroallergen sensitization is linked to decreased lung function in adults.
- The relationship between specific IgE levels and pulmonary function in pediatric asthma remains understudied.
- This study investigates common Korean aeroallergens and their impact on lung function in asthmatic children.
Purpose of the Study:
- To examine the correlation between specific IgE levels for Dermatophagoides pteronyssinus, Dermatophagoides farinae, Alternaria, and German cockroach allergens and pulmonary function in asthmatic children.
- To compare these correlations in asthmatic children versus a non-asthmatic control group.
- To identify which specific inhalant allergens are most associated with reduced lung function in pediatric asthma.
Main Methods:
- A cohort of 55 asthmatic children and 48 non-asthmatic children was recruited.
- Specific IgE levels for four major inhalant allergens were quantified using the CAP system FEIA.
- Pulmonary function was assessed via spirometry, measuring forced expiratory volume in 1 second (FEV(1)), forced vital capacity (FVC), FEV(1)/FVC ratio, and forced expiratory flow between 25% and 75% of FVC (FEF(25-75)).
Main Results:
- In asthmatic children, elevated specific IgE levels for Dermatophagoides farinae (Der f.) and Dermatophagoides pteronyssinus (Der p.) were significantly associated with reduced FEV(1), FEV(1)/FVC, and FEF(25-75).
- Specifically, higher Der f.-specific IgE correlated with decreased FEV(1) (r = -0.44) and FEF(25-75) (r = -0.33).
- Higher Der p.-specific IgE correlated with decreased FEV(1) (r = -0.37) and FEF(25-75) (r = -0.34). No significant correlations were found for German cockroach or Alternaria allergens, nor in the control group.
Conclusions:
- Sensitization to Dermatophagoides species (Der p. and Der f.) appears to be a significant factor contributing to diminished pulmonary function in asthmatic children.
- German cockroach and Alternaria sensitization did not show a significant association with reduced lung function in this pediatric asthma cohort.
- These findings highlight the importance of identifying specific allergen triggers for effective asthma management in children.
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