[Modulation of immune system cells by lactobacilli].

Area of Science:

• Immunology
• Microbiology
• Gastroenterology

Background:

• Lactobacilli are known for their beneficial effects on gut health.
• The immune system plays a crucial role in defending against enteric pathogens.
• Understanding the interaction between probiotics and the host immune system is vital for developing effective treatments.

Purpose of the Study:

• To evaluate the influence of lactobacilli on immune cell proliferation.
• To investigate the immunomodulatory effects of lactobacilli on T- and B-cell responses.
• To explore the protective mechanisms of lactobacilli against acute enteric infections.

Main Methods:

• Intragastric administration of viable lactobacilli and their filtrates to CBA mice.
• Modeling experimental infection using virulent Shigella dysenteriae.
• Evaluation of immune cell proliferative potential and T- and B-cell responses.

Main Results:

• Lactobacilli demonstrated a modulating influence on the formation of T- and B-cell immune responses.
• Probiotic administration affected immune homeostasis and cell-mediated immune reactions.
• Lactobacilli exhibited protective properties against Shigella dysenteriae infection.

Conclusions:

• Lactobacilli play a significant role in modulating the host immune system.
• These probiotics contribute to maintaining immune homeostasis and enhancing defense against enteric pathogens.
• The findings highlight the potential of lactobacilli as a therapeutic strategy for acute enteric infections.