Related Experiment Video

Updated: Aug 20, 2026

In Situ Exploration of Murine Megakaryopoiesis using Transmission Electron Microscopy
08:15

In Situ Exploration of Murine Megakaryopoiesis using Transmission Electron Microscopy

Published on: September 8, 2021

Histomorphometry of marrow megakaryocytes in experimental uraemia in rats

W Bogusłowicz1, D Lemancewicz, D Pawlak

  • 1Department of Human Anatomy, Medical University of Bialystok, Poland. anatomia@amb.edu.pl

Roczniki Akademii Medycznej W Bialymstoku (1995)
|January 11, 2005
PubMed

Uraemic patients frequently demonstrate tendencies towards life-threatening bleeding. Reduced platelet counts and their functional immaturity seem to be caused, among other things, by disorders in the system of marrow megakaryocytes. The aim of the study was a histomorphometric evaluation of marrow megakaryocytes in the course of experimental uraemia in rats. Uraemia was induced by means of right nephrectomy and a partial removal of the left kidney cortex in rats. Morphometric analysis was conducted, using the Microlmage program set. The number of MK, MK area, N/C, CDMK, CDNMK and MK cluster formation were analysed. Uraemic rats showed a reduction in the MK count and their area and an increase in the N/C ratio, CDMK, CDNMK and in the incidence of MK clusters. The results indicate that platelet disorders, observed in uraemia, can also be conditioned by disturbed maturation of MK.

More Related Videos

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Femoral Bone Marrow Aspiration in Live Mice07:10

Femoral Bone Marrow Aspiration in Live Mice

Published on: July 5, 2014

Related Concept Videos