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Antibiotic Selection00:57

Antibiotic Selection

Overview
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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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Updated: Jun 19, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Approaches to vancomycin-resistant enterococci.

Carlos Torres-Viera1, Louise-Marie Dembry

  • 1Yale New Haven Hospital and Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06504, USA. carlos.torres-viera@ynhh.org

Current Opinion in Infectious Diseases
|January 11, 2005
PubMed
Summary
This summary is machine-generated.

New antimicrobial drugs offer hope for treating vancomycin-resistant enterococci infections. Careful antibiotic use and infection control remain crucial for managing these resistant bacteria.

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Last Updated: Jun 19, 2026

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11:56

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12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Vancomycin-resistant enterococci (VRE) pose a significant challenge in healthcare settings.
  • Limited effective treatment options exist for VRE infections.
  • Emerging antimicrobial resistance necessitates the development of novel therapeutic agents.

Purpose of the Study:

  • To review recent publications on novel antimicrobial drugs for VRE treatment.
  • To assess the efficacy and safety of emerging VRE therapies.

Main Methods:

  • Systematic review of recent scientific literature.
  • Analysis of clinical trial data for new antimicrobial agents.
  • Evaluation of in-vitro activity and clinical data for emerging drugs.

Main Results:

  • New drugs like quinupristin-dalfopristin and linezolid are available but bacteriostatic against enterococci, with emerging resistance.
  • Daptomycin shows in-vitro bactericidal activity, but clinical data for serious infections are limited.
  • Ramoplanin, oritavancin, dalbavancin, and tigecycline are under investigation, with some not yet commercially available.

Conclusions:

  • While new drugs provide hope, VRE treatment remains challenging.
  • Rational antibiotic use, strict guidelines, and infection control are essential for VRE management.
  • Continued research and development of effective VRE therapies are critical.