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[The difference in distribution of HCV genotypes between patients infected with HCV by transfusion and
Insights
Hepatitis C virus (HCV) genotype distribution in China showed similar patterns in northern and southern regions. However, significant differences were observed between transfusion-acquired and other routes of HCV infection.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Hepatitis C virus (HCV) infection remains a global health concern.
- Understanding HCV genotype distribution is crucial for effective treatment and prevention strategies.
Purpose of the Study:
- To determine the distribution of HCV genotypes in northern and southern China.
- To compare HCV genotype prevalence between transfusion- and non-transfusion-acquired infections.
Main Methods:
- Genotyping of HCV from chronic hepatitis C patients across nine Chinese cities using PCR and restriction endonuclease digestion.
- Statistical analysis to compare genotype distribution regionally and by transmission route.
Main Results:
- HCV genotypes 1b and 2a were predominant in China (76.64% and 18.22%, respectively).
- Genotype 3b (5.14%) and the novel genotype 4a were identified.
- No significant difference in HCV genotype distribution was found between northern and southern China.
- Significant differences in genotype distribution were observed between transfusion- and non-transfusion-acquired HCV infections (P=0.036).
Conclusions:
- HCV genotype distribution in China is geographically uniform across northern and southern regions.
- Transmission route significantly influences HCV genotype prevalence, with transfusion-related infections showing higher rates of monogenotype 1b compared to other routes.
Objective:
To investigate the HCV genotypes distribution in northern and southern cities in China and the difference between patients infected with HCV by transfusion and non-transfusion routes.
Methods:
The HCV genotypes of the patients with chronic hepatitis C from 9 cities belonging to different regions were genotyped by the PCR products of 5 prime untranslated region NTR digested with restriction endonucleases, and the HCV genotypes distribution among different cities or between the patients infected with HCV through transfusion and other routes was analyzed.
Results:
The HCV genotypes of 214 in 219 cases were determined; 197 patients were infected with monogenotype HCV. The major epidemic genotypes of HCV isolates in China were 1b (76.64%) and 2a (18.22%), but 5.14% of patients were infected with HCV belonging to genotype 3b and this was the first report that there is genotype 4a in China. The HCV genotype distribution was not different in northern and southern areas, but was significantly different between patients infected with HCV through transfusion and non-transfusion routes (P=0.036). In patients infected trough transfusion, the rates of monogenotype HCV infection and genotype 1b were 93.88% and 76.87%, respectively, which were higher than those (86.57% and 58.21%) in the patients infected with HCV through non-transfusion routes. The rate of patient infected with mixed genotype HCV strains in non-transfusion group was 13.43%, which was higher than that (6.12%) of patients in transfusion group.
Conclusion:
The HCV genotype distribution in northern and southern regions were similar, but was significantly different between the patients infected through transfusion and other routes.
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