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Cardiologic and neurologic findings in left ventricular hypertrabeculation/non-compaction related to wall thickness,

Claudia Stöllberger1, Josef Finsterer

  • 12nd Medical Department, KA Rudolfstiftung, Steingasse 31/18, A-1030 Wien, Osterreich, Austria. claudia.stoellberger@chello.at

European Journal of Heart Failure
|January 12, 2005
PubMed

Insights

Left ventricular hypertrabeculation/noncompaction (LVHT) is a rare heart condition often linked to neuromuscular disorders. This study found LVHT is more common in dilated ventricles and cardiac issues may worsen with age.

Area of Science:

  • Cardiology
  • Neurology
  • Genetics

Background:

  • Left ventricular hypertrabeculation/noncompaction (LVHT) is a rare cardiac anomaly characterized by excessive trabeculations in the left ventricle.
  • LVHT is frequently associated with neuromuscular disorders (NMD).
  • LVHT can present with dilated, hypertrophic, or normally-dimensioned ventricles, with or without systolic dysfunction.

Purpose of the Study:

  • To investigate differences in cardiologic and neurologic findings among LVHT patients based on echocardiographically determined left ventricular size, systolic function, and wall thickness.

Main Methods:

  • Echocardiography was used to diagnose LVHT in 77 patients.
  • Patients were categorized into 'dilative' (n=43), 'hypertrophic' (n=18), and 'normally-dimensioned' (n=16) LVHT groups.
  • Neurologic and cardiac findings were compared across these groups.

Main Results:

  • Dilative LVHT patients were older than hypertrophic or normally-dimensioned LVHT patients.
  • The prevalence of NMD was similar across all LVHT groups (63% dilative, 67% hypertrophic, 56% normally-dimensioned).
  • LVHT was more frequently observed in dilated ventricles compared to hypertrophic ones.

Conclusions:

  • LVHT is more prevalent in dilated ventricles, but NMD prevalence is consistent across different LVHT morphologies.
  • Cardiac abnormalities associated with LVHT may progress over time.
  • Further research is needed to understand the progression and management of LVHT.

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