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[Mesangial glomerulonephritis and intermediate uveitis].

E Román1, I Zamora, F Vera

  • 1Servicio de Pediatría Hs Orihuela, Hospital Infantil La Fe. elenaroman@ono.com

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|January 15, 2005
PubMed
Summary

This study reports a rare pediatric case of intermediate uveitis and mesangial glomerulonephritis with immune deposits. It highlights the potential link between these conditions and the need for systemic evaluation in children with uveitis.

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Area of Science:

  • Ophthalmology
  • Nephrology
  • Pediatrics

Background:

  • Uveitis in children is less common than in adults and can be idiopathic or associated with systemic diseases.
  • Noninfectious diseases with renal involvement include tubulointerstitial nephritis and uveitis syndrome (TINU) and mesangial glomerulonephritis, sometimes seen with Behçet's disease.

Observation:

  • A 14-year-old girl presented with intermediate uveitis (pars planitis), characterized by eye redness, pain, and "snow-banks" in the pars plana.
  • She exhibited microscopic hematuria and intermittent proteinuria, which worsened with ocular exacerbations.

Findings:

  • Renal biopsy revealed mild mesangial matrix increase and cellularity, with normal tubulointerstitial structures.
  • Mesangial deposition of IgA and IgG immunoglobulins was observed, marking the first pediatric report of intermediate uveitis with immune-deposit mesangial glomerulonephritis.

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Implications:

  • This case suggests a potential common immunological pathogenesis, possibly involving immune complexes, between uveitis and glomerulonephritis.
  • Routine screening for extra-ocular and renal manifestations is crucial in pediatric uveitis patients, necessitating long-term systemic follow-up.