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Human coronavirus NL63 infection in Canada
Nathalie Bastien1, Kelly Anderson, Laura Hart
1National Microbiology Laboratory, Canadian Science Center for Human and Animal Health, Winnipeg, Manitoba, Canada.
The Journal of Infectious Diseases
|January 19, 2005
Summary
Human coronavirus NL63 (HCoV-NL63) circulates globally. This study detected HCoV-NL63 in Canadian respiratory specimens, with common symptoms including fever and cough, indicating its widespread presence.
Area of Science:
- Virology
- Respiratory Medicine
- Public Health
Background:
- Human coronavirus NL63 (HCoV-NL63) was recently isolated, prompting investigation into its role in respiratory illnesses.
- Understanding the geographical distribution and clinical impact of emerging coronaviruses is crucial for public health surveillance.
Purpose of the Study:
- To determine the presence and activity of HCoV-NL63 in respiratory specimens collected in Canada.
- To describe the clinical characteristics and patient demographics associated with HCoV-NL63 infection.
Main Methods:
- Retrospective analysis of 525 respiratory specimens collected in Canada during the 2001-2002 winter season.
- Detection of HCoV-NL63 using molecular diagnostic methods (details not specified in abstract).
Main Results:
- HCoV-NL63 was detected in 19 out of 525 specimens (3.6%), with activity observed from January to March 2002.
- Infected patients ranged from 1 month to 100 years old (median age 37).
- Commonly reported symptoms included fever (79%), sore throat (26%), and cough (47%); 4 patients required hospitalization.
Conclusions:
- This study provides evidence for the circulation of HCoV-NL63 in Canada during the 2001-2002 winter.
- HCoV-NL63 is associated with a range of respiratory symptoms and can lead to hospitalization.
- The findings support the global distribution of HCoV-NL63.