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Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies
Yourong Fu1, Shicheng Yang, Seong Hoon Jeong
1Purdue University, Departments of Pharmaceutics and Biomedical Engineering, West Lafayette, Indiana 47907-2091, USA.
Critical Reviews in Therapeutic Drug Carrier Systems
|January 22, 2005
Summary
Fast disintegrating tablets (FDTs) offer convenient oral drug delivery without water. This review details various FDT technologies and formulation enhancements for improved dissolution and patient compliance.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Fast disintegrating tablets (FDTs) are increasingly popular in the pharmaceutical industry due to their ease of administration.
- These tablets disintegrate rapidly in the oral cavity without the need for water, facilitating the delivery of active pharmaceutical ingredients.
Purpose of the Study:
- To review and describe various formulations and technologies for developing FDTs.
- To discuss methods for enhancing the properties of FDTs, including disintegration and dissolution.
- To cover related aspects such as taste-masking and clinical evaluations.
Main Methods:
- Review of existing literature on FDT technologies.
- Detailed description of technologies including lyophilization, molding, sublimation, and compaction.
- Discussion of enhancement approaches like spray-drying, moisture treatment, sintering, and use of sugar-based disintegrants.
Main Results:
- Multiple FDT technologies have been developed to achieve rapid oral disintegration.
- Various methods exist to enhance FDT properties, improving their performance.
- Taste-masking and clinical studies are integral to FDT development.
Conclusions:
- The field of FDTs has seen significant growth, driven by the demand for convenient drug delivery.
- A range of technologies and formulation strategies are available to create effective FDTs.
- Further research and development continue to refine FDTs for improved therapeutic outcomes.
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