Related Experiment Video
Updated: Aug 19, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Contractile function of the smooth-muscle wall and its adrenergic regulation in megaureter
I S Mudraya1, V I Kirpatovskii, I V Kazanskaya
1Institute of Urology, Ministry of Health of Russian Federation, Moscow, Russia. sabirzianova@yandex.ru
Abstract:
We demonstrated disordered contractile capacity of megaureters formed against the background of reflux, organic or functional obstruction. The rhythmic and tonic contractions were suppressed in the megaureters with organic obstruction in comparison with megaureters caused by reflux. Norepinephrine stimulation induced pronounced pressor responses in obstructive megaureters. The state of the smooth-muscle walls of megaureters with functional obstruction was characterized by high tone, weak phase contractions, and increased capacity to pressor tonic reactions induced by norepinephrine.
More Related Videos
06:36A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
08:30Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents
Published on: January 31, 2020
Related Concept Videos
Anatomy of the Genitourinary System II: Bladder and Urethra
The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
Ureters
Urethra
The anatomy of the urethra differs between males and females. In females, the urethra is short, measuring about 3–4 cm in length, and opens anterior to the vaginal opening. In males, the urethra is longer and passes through the penis, serving dual purposes: expelling urine and ejaculating semen. The male urethra is...
Smooth Muscle Contraction
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
Adrenergic Receptors: ɑ Subtype
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase C—inositol-1,4,5-trisphosphate...