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Updated: Aug 19, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
In vitro regulation of cell behavior by calcium phosphates synthesized by the mechanochemical method
A V Karlov1, I A Khlusov, N S Pozhen'ko
1Center for Orthopedics and Medical Material Technology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. khl@comm.tomsk.ru
Abstract:
Biological activity of eight hydroxyapatite powders synthesized by the mechanochemical method was studied in vitro. Introduction of copper and zinc atoms into synthetic hydroxyapatite structure promotes cell adhesion. Hydroxyapatites obtained by the mechanochemical method are promising base for a new class of materials and coatings with regulated bioactivity for orthopedics and traumatology.
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