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Updated: Mar 28, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
Effect of lipid-lowering drug therapy on small-dense low-density lipoprotein
James M Backes1, Cheryl A Gibson
1Department of Pharmacy Practice, School of Pharmacy, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160-7231, USA. jbackes@kumc.edu
Objective:
To review the effects of lipid-lowering therapy on small-dense low-density lipoprotein cholesterol (sdLDL-C).
Data Sources:
Literature was obtained from MEDLINE (1989-September 2004) and references of selected articles. Key search terms included small-dense LDL-C and lipid-lowering drug therapy.
Data Synthesis:
Statins, fibrates, and niacin have demonstrated favorable effects on sdLDL-C, especially among patients with mixed dyslipidemia or hypertriglyceridemia. These effects include a reduction of sdLDL-C and/or a shift to the larger, less atherogenic LDL-C.
Conclusions:
Data suggest that statins, fibrates, and niacin are effective at reducing concentrations of sdLDL-C and possibly normalizing LDL-C subclasses.
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