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Updated: Aug 19, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
Relative rates of gene fusion and fission in multi-domain proteins
Sarah K Kummerfeld1, Sarah A Teichmann
1MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK, CB2 2QH. skk@mrc-lmb.cam.ac.uk
Abstract:
During evolution genes can produce more complex proteins by gene fusion or less complex proteins by gene fission. Considering proteins from 131 completely sequenced genomes from all three kingdoms of life, we identified 2869 groups of multi-domain proteins as a single protein in certain organisms and as two or more smaller proteins with equivalent domain architectures in other organisms. We found that fusion events are approximately four times more common than fission events, and we established that, in most cases, any particular fusion or fission event only occurred once during the course of evolution.
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