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Multifunctional drug delivery system using starch-alginate beads for controlled release
Young Joo Kim1, Hyun Gyu Park, Young Lyul Yang
1National Genome Information Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong, Yuseong-gu, Daejon 305-333, Korea.
Biological & Pharmaceutical Bulletin
|February 3, 2005
Summary
Novel starch-containing alginate beads offer controlled drug delivery and heavy metal removal. Multi-coating strategies enable tunable drug release, enhancing alginate gel-based drug delivery systems (DDS).
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Alginate-based hydrogels are widely explored for drug delivery systems (DDS).
- Developing stable and controllable DDS remains a significant challenge.
- Incorporating starch into alginate beads offers potential for improved handling and functionality.
Purpose of the Study:
- To develop a novel starch-containing alginate bead as a drug delivery system.
- To investigate the effect of multi-coating on drug release kinetics.
- To explore the potential of these beads for heavy metal adsorption.
Main Methods:
- Fabrication of starch-alginate composite beads.
- Application of alginate multi-coating technique.
- In vitro release studies using L-phenylalanine as a model drug.
- Assessment of heavy metal (lead) adsorption capacity.
Main Results:
- Starch-alginate beads maintained their shape after drying.
- Multi-coating significantly increased the latent time and controlled the release rate of L-phenylalanine.
- Latent times increased from negligible to 70 minutes with increased coating layers.
- Alginate component demonstrated effective adsorption of lead ions.
Conclusions:
- Starch-containing alginate beads provide a stable platform for drug delivery.
- The multi-coating strategy offers a simple method to tune drug release profiles.
- These multifunctional beads show promise for advanced alginate gel-based DDS with added detoxification capabilities.