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Updated: Aug 19, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Thrombus formation on an atrial septal defect closure device
Adam C Clarke1, Kristine J Hirsch, Catherine M Kells
1Department of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia. aclarke@avdha.nshealth.ca
Insights
Transcatheter closure of atrial septal defects (ASDs) is common, but device-related thrombus can occur. This case emphasizes using transesophageal echocardiography and anticoagulation during ASD closure procedures to prevent complications.
Area of Science:
- Cardiology
- Interventional Cardiology
- Congenital Heart Disease
Background:
- Atrial septal defects (ASDs) are common congenital heart conditions presenting in adulthood.
- Percutaneous closure is a standard treatment for secundum-type ASDs.
- Complications from transcatheter ASD closure are infrequently reported.
Purpose of the Study:
- To report a rare complication of transcatheter ASD closure: rapid thrombus formation on the device.
- To underscore the importance of intraprocedural monitoring and anticoagulation strategies.
Main Methods:
- Case report detailing a patient undergoing percutaneous closure of an ASD.
- Utilized transesophageal echocardiography (TEE) for procedural guidance.
- Managed the patient with periprocedural anticoagulation.
Main Results:
- A large thrombus rapidly formed on the atrial septal defect closure device.
- Transesophageal echocardiography was crucial for identifying the thrombus.
- Anticoagulation management was implemented.
Conclusions:
- Device-related thrombus is a potential complication of transcatheter ASD closure.
- Transesophageal echocardiography is vital for real-time assessment during the procedure.
- Periprocedural anticoagulation may play a role in preventing such complications.
Abstract:
Atrial septal defects (ASDs) are the most prevalent form of congenital heart disease presenting after childhood. Percutaneous closure has become a safe and effective strategy for managing adults with secundum-type ASDs. Reports on complications are rare. The present report discusses a case of rapid formation of a large thrombus on an ASD transcatheter closure device. The case highlights the importance of transesophageal echocardiography during the procedure and supports the role of periprocedural anticoagulation in transcatheter ASD closures.
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