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Related Experiment Videos

Palmitic acid kinetics in fasting, traumatized patients.

R H Birkhahn1, R J Cardwell, G C Birkhahn

  • 1Department of Surgery, Medical College of Ohio, Toledo.

The Journal of Trauma
|April 1, 1992
PubMed
Summary

Free fatty acid oxidation does not increase energy expenditure after trauma. Studies show that despite higher energy needs in trauma patients, plasma free fatty acids and palmitate kinetics remain unchanged, indicating no contribution to elevated energy expenditure.

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Area of Science:

  • Metabolism and Nutrition
  • Trauma and Critical Care

Background:

  • Elevated energy expenditure is a hallmark of the hypermetabolic response to trauma.
  • The specific role of free fatty acid (FFA) oxidation in this increased energy expenditure remains poorly understood.

Purpose of the Study:

  • To investigate the contribution of free fatty acid oxidation to the elevated energy expenditure observed after trauma.

Main Methods:

  • A study involving six control subjects and six traumatized patients who underwent a 48-hour fast.
  • A primed continuous infusion of (1-14C)palmitate was administered to measure plasma palmitate and total FFA kinetics.
  • Measurements included urinary nitrogen losses and resting energy expenditure (REE) relative to predicted values.

Main Results:

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  • Traumatized patients exhibited significantly higher urinary nitrogen losses and a greater ratio of measured to predicted REE (+36% vs. -6%).
  • Plasma FFA and palmitate concentrations were comparable between control and traumatized groups.
  • No significant alterations in the turnover or oxidation rates of plasma palmitate and total FFAs were observed in traumatized patients.

Conclusions:

  • Plasma free fatty acids and palmitate do not contribute to the increased energy expenditure following multiple trauma.
  • The study highlights that other metabolic pathways are likely responsible for the hypermetabolic state post-trauma.