Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Formulation strategies for absorption windows.

Stanley S Davis1

  • 1Institute of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. stanley.davis@nottingham.ac.uk

Drug Discovery Today
|February 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model.

Pharmaceutical research·2008
Same author

Design and evaluation of an emulsion vehicle for paclitaxel. II. Suppression of the crystallization of paclitaxel by freeze-drying technique.

Drug development and industrial pharmacy·2007
Same author

Evaluation of effect of ephedrine on the transport of drugs from the nasal cavity to the systemic circulation and the central nervous system.

Journal of drug targeting·2007
Same author

The use of soluble polymers and polymer microparticles to provide improved vaccine responses after parenteral and mucosal delivery.

Vaccine·2006
Same author

Advances in the use of tocols as drug delivery vehicles.

Pharmaceutical research·2006
Same author

Design and evaluation of an emulsion vehicle for paclitaxel. I. Physicochemical properties and plasma stability.

Pharmaceutical research·2004
Same journal

Inorganic nanoparticles for diagnostics, drug delivery and therapy for solid tumors.

Drug discovery today·2026
Same journal

HDAC11 as a potential therapeutic target for Alzheimer's disease.

Drug discovery today·2026
Same journal

From biologics to small-molecule modulators: The evolving landscape of interleukin-targeted therapeutics.

Drug discovery today·2026
Same journal

Targeting the GLP-1 receptor pathways for dual management of obesity and depression.

Drug discovery today·2026
Same journal

Chemical intervention strategies targeting MYC for cancer therapy.

Drug discovery today·2026
Same journal

How many protein pairs can we chemically target?

Drug discovery today·2026
See all related articles

Drug delivery systems can overcome poor oral bioavailability by increasing drug residence time in the gastrointestinal tract. This review explores bioadhesive microspheres and gastroretentive systems for enhanced drug absorption.

Area of Science:

  • Pharmacology
  • Drug Delivery
  • Gastrointestinal Physiology

Background:

  • Oral drug bioavailability is often limited by absorption windows in the proximal gastrointestinal tract.
  • Developing controlled-release formulations is challenging due to rapid transit of drugs past absorption sites.

Purpose of the Study:

  • To review methods for increasing drug formulation residence time at or above intestinal absorption windows.
  • To discuss strategies for enhancing oral drug bioavailability.

Main Methods:

  • Review of current approaches for prolonging drug residence time in the gastrointestinal tract.
  • Discussion of bioadhesive microspheres and gastroretentive dosage systems.
  • Analysis of factors influencing gastrointestinal transit, including food effects.

Related Experiment Videos

Main Results:

  • Two primary strategies are explored: bioadhesive microspheres for slow intestinal transit and gastroretentive dosage systems (multiparticulates or single-unit systems).
  • Understanding gastrointestinal transit dynamics is crucial for designing effective drug delivery systems.

Conclusions:

  • Strategies like bioadhesive microspheres and gastroretentive systems show promise for improving oral drug bioavailability.
  • Rational design of drug delivery systems requires a thorough understanding of human gastrointestinal transit and influencing factors.