Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural stem cells: progenitors or panacea?

Corinna Klein1, Gord Fishell

  • 1Developmental Genetics Program, The Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University Medical Center, New York, NY 10016, USA.

Developmental Neuroscience
|February 16, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive function depends upon <i>Satb2</i> gene dosage in cortical projection neurons.

bioRxiv : the preprint server for biology·2026
Same author

Feature-specific threat coding in lateral septum guides defensive action.

Nature·2026
Same author

Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Nature·2026
Same author

Contributors to Parenting Stress in Tuberous Sclerosis Complex at Preschool Age.

Pediatric neurology·2026
Same author

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Nature·2026
Same author

Non-reciprocal callosal projections and input gradients underlie interhemispheric communication in binocular visual cortex.

Cell reports·2026
Same journal

Microbiota-Based Interventions Differentially Rescue Gut and Social Behavior Phenotypes in Drosophila with Kdm5 Deficiency.

Developmental neuroscience·2026
Same journal

Maternal Infection Induces Neuronal Structure and Behavioural Alterations in Experimental Meningitis Rat Model.

Developmental neuroscience·2026
Same journal

Development of the Gut Microbiota throughout the First Year of Life and Its Association with Socio-Emotional Development into Childhood.

Developmental neuroscience·2026
Same journal

Intranasal Inhibition of Tropomyosin Receptor Kinase B Signaling during Early Postnatal Development Disrupts Growth and Sensorimotor Maturation in Neonatal Rodents.

Developmental neuroscience·2026
Same journal

Long-Term Consequences of Preterm Birth: A Lifespan Perspective.

Developmental neuroscience·2026
Same journal

From Womb to Weaning: Microbial Signals That Shape the Developing Brain.

Developmental neuroscience·2026
See all related articles

Neural stem cells (NSCs) in the brain are reviewed to determine if they are totipotent precursors or restricted progenitors. Research compares in vitro data with NSC transplantation into developing, adult, and lesioned brains.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Neural stem cells (NSCs) reside within specialized stem cell niches.
  • The totipotency and restricted potential of endogenous NSCs remain under investigation.
  • Understanding NSC behavior is crucial for brain development and repair.

Purpose of the Study:

  • To review recent findings on endogenous neural stem cell populations in the embryonic and adult brain.
  • To compare in vitro data with in vivo transplantation studies of NSCs.
  • To elucidate the role of the stem cell niche in maintaining NSC potential.

Main Methods:

  • Review of existing literature on neural stem cells.
  • Analysis of in vitro studies on NSC behavior.

Related Experiment Videos

  • Examination of data from NSC transplantation experiments in various brain conditions.

    • Main Results:

    • Recent research provides insights into the nature of endogenous NSCs.
    • In vitro and in vivo studies offer complementary perspectives on NSC potential.
    • The stem cell niche environment influences NSC maintenance and differentiation.

    Conclusions:

    • The plasticity and potential of neural stem cells are influenced by their niche.
    • Further research is needed to fully understand NSC behavior in different brain contexts.
    • Comparative analysis of in vitro and in vivo data is essential for advancing NSC research.