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Amalgam exposure and neurological function.

Albert Kingman1, James W Albers, Joseph C Arezzo

  • 1Division of Clinical Research and Health Promotion, National Institute of Dental and Craniofacial Research, National Institutes of Health, 45 Center Drive, Room 4As-25U, Bethesda, MD 20892-6401, USA. Albert.Kingman@nih.gov

Neurotoxicology
|February 17, 2005
PubMed
Summary

This study found no evidence that dental amalgam fillings cause clinically apparent neurological harm. A minor sub-clinical effect on sensation was noted in non-diabetic individuals, but without functional impairment.

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Area of Science:

  • Neurology
  • Dental Materials Science
  • Environmental Health

Background:

  • Concerns persist regarding the neurological safety of silver-mercury amalgam dental fillings.
  • Widespread population exposure necessitates thorough investigation of potential nervous system effects.

Purpose of the Study:

  • To investigate potential associations between dental amalgam exposure and neurological abnormalities in Vietnam-era veterans.
  • To assess the relationship between amalgam exposure and clinical neurological signs and peripheral neuropathy.

Main Methods:

  • Utilized data from 1663 dentate participants in the Air Force Health Study (AFHS), including controls and dioxin-exposed "Ranch Hand" veterans.
  • Assessed neurological outcomes including clinical signs, vibrotactile thresholds, and peripheral neuropathy levels.

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  • A limitation was the absence of more sensitive measures like nerve conduction studies.

    • Main Results:

    • No significant associations were found between amalgam exposure and clinical neurological signs or peripheral neuropathy.
    • A statistically significant, but sub-clinical, association was detected between amalgam exposure and vibrotactile sensation in non-diabetic participants.
    • This sub-clinical finding was not linked to symptoms, evident neuropathy, or functional impairment.

    Conclusions:

    • The study found no evidence to support the hypothesis that dental amalgam exposure causes adverse, clinically evident neurological effects.
    • Findings indicate that amalgam exposure is not associated with neurological signs or clinically apparent peripheral neuropathy.