Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Invasive group A streptococcus infections.

D L Stevens1

  • 1Department of Medicine, University of Washington School of Medicine, Seattle.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HMSN and HNPP: Laboratory Service Provision in the South West of England-Two Years' Experience.

Annals of the New York Academy of Sciences·2017
Same author

Sensitization of enteric neurons to morphine by HIV-1 Tat protein.

Neurogastroenterology and motility·2015
Same author

Chromosome aberration induction is dependent on the spatial distribution of energy deposition through a cell nucleus.

Radiation protection dosimetry·2010
Same author

Spontaneous Rupture Of the Axillary Artery.

Anales de cirugia·2010
Same author

The first case of Pasteurella canis bacteremia: a cirrhotic patient with an open leg wound.

Infection·2010
Same author

Innate immune recognition of, and response to, Clostridium sordellii.

Anaerobe·2009
Same journal

Antibiotic Treatment Duration for Uncomplicated Monomicrobial Enterococcal Bloodstream Infection: A Multicenter Target Trial Emulation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Larger Blood Volume Increases Detection of Fastidious Mycobacteria and Fungi in Blood Culture.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Anticalcitonin: Limited utility of a context-dependent biomarker demonstrated in another real-world data set.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Procalcitonin Testing in Community-Acquired Pneumonia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Wanted: A Relevant Correlate of Protection for Dengue Vaccines.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Safety and Immunogenicity of the Live-Attenuated Quadrivalent Dengue Vaccine V181 Compared With Butantan-DV Among Healthy Adults in Brazil: A Randomized, Double-Blind, Phase 2 Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
See all related articles

Severe group A streptococcus (GAS) infections emerged in the late 1980s, causing shock and high mortality. This study details clinical features, pathogenesis, and proposes future treatments for invasive GAS disease.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Critical Care Medicine

Background:

  • The late 1980s saw a rise in severe group A streptococcus (GAS) infections, characterized by shock, bacteremia, and acute respiratory distress syndrome.
  • These invasive GAS infections predominantly affected healthy adolescents and adults across the US, Europe, and Australia, with mortality rates up to 30%.

Purpose of the Study:

  • To present and compare the clinical and demographic features of streptococcal bacteremia, myositis, and necrotizing fasciitis with streptococcal toxic shock syndrome.
  • To discuss current concepts in the pathogenesis of invasive streptococcal infections, focusing on the interplay between GAS virulence factors and host defenses.
  • To propose novel treatment strategies for severe streptococcal infections.

Main Methods:

Related Experiment Videos

  • Clinical and demographic data from patients with invasive streptococcal infections were analyzed.
  • Features of streptococcal toxic shock syndrome were compared with those of streptococcal bacteremia, myositis, and necrotizing fasciitis.
  • Pathogenesis was explored through the lens of GAS virulence factors and host immune responses.

    • Main Results:

    • Invasive GAS strains, particularly M types 1 and 3, were associated with pyrogenic exotoxins A or B, or both.
    • Streptococcal toxic shock syndrome is defined by deep-seated infection, shock, and multiorgan failure.
    • GAS infections presented with diverse clinical manifestations including bacteremia, myositis, and necrotizing fasciitis.

    Conclusions:

    • Understanding the clinical spectrum and pathogenesis of invasive GAS is crucial for effective management.
    • Future treatment approaches should consider the specific virulence factors of GAS and host immune interactions.
    • Prompt recognition and intervention are vital for improving outcomes in severe streptococcal infections.