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Published on: June 14, 2016
[Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium]
Haili Lü1, Yongqing Guo, Zhen Dong
1Department of Otolaryngology-Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130031, China.
Objective:
To examine the expression of MUC5AC in human nasal polyp and inferior turbinate epithelium, to evaluate the relationship between MUC5AC and the increased mucous secretions in polyps and chronic hypertrophy rhinitis.
Method:
With immunohistochemistry ABC and HE dyeing, twenty-seven polyps, nineteen chronic hypertrophy rhinitis and eleven normal inferior turbinates epithelium were applied to this study.
Result:
The number of MUC5AC+ cells in nasal polyps and chronic hypertrophy rhinitis was significantly bigger than that in normal inferior turbinates (P < 0.05), and the MUC5AC+ cells were mainly concentrate on the goblet cells.
Conclusion:
MUC5AC is highly expressed in epithelium of human polyps and chronic hypertrophy rhinitis inferior turbinates, and MUC5AC takes part in increasing secretion in polyps and chronic hypertrophy rhinitis.
