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Updated: Aug 19, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
Published on: November 29, 2015
[Radial optic neurotomy in ischemic central retinal vein occlusion]
1Klinik und Poliklinik für Augenheilkunde, Universitäts-Krankenhaus Hamburg-Eppendorf. RCLerche@uke.uni-hamburg.de
Background:
Loss of visual acuity due to ischemic retinal vein occlusion (RVO) is still a major problem in ophthalmology. Prognosis is poor and loss of vision is a severe risk. New approaches for treatment like systemic fibrinolysis and surgical procedures have been suggested.
Patients And Methods:
In a clinical trial 8 patients with ischemic CRVO underwent surgical decompression. Strict criteria of inclusion were maintained. Radial optic neurotomy (RON) was performed 0.25-5 months after retinal vein occlusion. Follow up-time was 3 months. Visual acuity and incidence of typical complications after RVO were the main points of interest in our scientific evaluation.
Results:
Visual acuity improved significantly after the surgical procedure. For ischemic CRVO EDTRS charts increased from logMAR 1.0 (decimal 0.17) to 0.68 (0.30) at 3 months after surgery. Surgical or early complications did not occur within 3 months. The recovery of retinal blood flow during fluorescein angiography was investigated in 75 % of the patients. A resolution of non perfusion-areas could be detected in 50 % of the eyes.
Conclusions:
For patients with retinal vein occlusion RON seems to be a safe and feasible procedure. The results indicate the potential to improve visual acuity while typical complications due to surgery or vein occlusion did not occur during the first three months.
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