Related Experiment Video

Updated: Aug 17, 2026

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Multiple endocrine neoplasia type 1

Gerard M Doherty1

  • 1NW Thompson Professor of Surgery, University of Michigan, Ann Arbor, Michigan, USA. gerardd@umich.edu

Journal of Surgical Oncology
|February 19, 2005
PubMed

Insights

Multiple endocrine neoplasia-1 (MEN-1) is an inherited syndrome caused by MEN1 gene mutations. Management focuses on detecting and caring for associated tumors like parathyroid, pancreatic, and pituitary adenomas.

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Multiple endocrine neoplasia-1 (MEN-1) is an autosomal dominant inherited syndrome.
  • It results from inactivating mutations in the MEN1 gene, which encodes the tumor-suppressor protein menin.
  • MEN-1 is characterized by specific neoplastic manifestations.

Purpose of the Study:

  • To outline the key features and manifestations of MEN-1.
  • To emphasize the importance of understanding and managing this condition.
  • To provide guidance on detecting and caring for MEN-1 associated tumors.

Main Methods:

  • Review of the genetic basis of MEN-1, focusing on MEN1 gene mutations.
  • Description of the common and less common neoplastic manifestations.
  • Discussion of clinical management strategies for MEN-1 patients.

Main Results:

  • MEN-1 commonly involves hyperparathyroidism (parathyroid adenomas), pancreatic neuroendocrine tumors, and pituitary adenomas.
  • Less frequent neoplastic conditions can also occur in MEN-1 patients.
  • Early detection and proactive management are crucial for patient care.

Conclusions:

  • MEN-1 is a complex inherited endocrine neoplasia syndrome.
  • While incurable, MEN-1 is manageable with comprehensive care.
  • Knowledge of potential complications and management approaches is essential for healthcare providers.

More Related Videos

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...