Changes in the blood lipid-transporting system in rats over the first day of experimental peritonitis

Changes in the lipid spectrum of blood plasma and composition of high-density lipoproteins in outbred albino rats were studied during early stages of experimental peritonitis. We revealed an increase in lecithin:cholesterol acyltransferase activity, activation of lipolytic production of high-density lipoproteins from very-low-density lipoproteins, and substitution of arachidonic acid in cholesterol esters for dihomo-gamma-linoleic acid 7 h after induction of peritonitis. After 24 h the protein composition and functional activity of high-density lipoproteins was modified and the amount of saturated fatty acids in cholesterol esters increased.