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Related Experiment Videos

Primary irritant dermatitis from topical clioquinol.

M Kero, M Hannuksela, A Sothman

    Contact Dermatitis
    |March 1, 1979
    PubMed
    Summary

    Topical clioquinol in creams can cause irritant dermatitis. Crystal size did not influence the development of this skin reaction in patients using these preparations.

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    Area of Science:

    • Dermatology
    • Toxicology
    • Pharmacology

    Background:

    • Topical clioquinol has been used in dermatological preparations.
    • Potential for adverse skin reactions exists with topical drug use.

    Purpose of the Study:

    • To investigate primary irritant dermatitis caused by clioquinol.
    • To determine if clioquinol crystal size affects irritant potential.

    Main Methods:

    • Studied seven patients with primary irritant dermatitis from clioquinol.
    • Recorded contact hypersensitivity in 35 eczema patients.
    • Performed challenge tests with varying crystal sizes of clioquinol.

    Main Results:

    • Seven patients developed irritant dermatitis from topical clioquinol.
    • Thirty-five patients showed contact hypersensitivity to clioquinol.
    • Challenge tests indicated crystal size did not alter irritant dermatitis.

    Conclusions:

    • Clioquinol in topical preparations can induce primary irritant dermatitis.
    • The crystal size of clioquinol does not appear to influence its irritant capacity.

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