Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treating learning impairments improves memory performance in multiple sclerosis: a randomized clinical trial.

Nancy D Chiaravalloti1, John DeLuca, Nancy B Moore

  • 1Kessler Medical Rehabilitation Research and Education Corporation, West Orange, NJ 07052, USA. nchiaravalloti@kmrrec.org

Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive rehabilitation in contemporary neuropsychological practice: an exploratory survey of service delivery, reimbursement, and perceived barriers.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2026
Same author

Profiles of Quality of Life Outcomes Observed in Rehabilitation Patients Using Latent Profile Analysis.

Archives of physical medicine and rehabilitation·2026
Same author

Evidence-Based Cognitive Rehabilitation for Persons With Multiple Sclerosis: An Updated Systematic Review 2016 to 2024.

Archives of physical medicine and rehabilitation·2026
Same author

Increased functional network connectivity following cognitive rehabilitation in progressive multiple sclerosis with moderate to severe disabilty: findings from the CogEx study.

Journal of neurology·2026
Same author

Looking Beyond Dose: Identifying Responders and Non-Responders to RehaCom Computerized Cognitive Rehabilitation in Progressive MS-The CogEx Study.

Neurorehabilitation and neural repair·2026
Same author

Using confirmatory factor analysis to identify symptom clusters in individuals with acquired disabilities.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026

This study found that the Story Memory Technique (SMT) significantly improved learning in multiple sclerosis (MS) patients with moderate to severe learning deficits. Memory rehabilitation is effective for MS-related cognitive impairment.

Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) frequently causes cognitive impairments, particularly learning deficits.
  • These deficits significantly impact patients' daily functioning and quality of life.
  • Existing memory rehabilitation strategies for MS may not be universally effective.

Purpose of the Study:

  • To evaluate the efficacy of the Story Memory Technique (SMT) in improving learning and memory in individuals with MS.
  • To determine if SMT benefits are dependent on the severity of initial learning impairment.
  • To assess the long-term effects of SMT on memory performance.

Main Methods:

  • A randomized clinical trial involving 29 participants with definite MS and documented learning deficits.

Related Experiment Videos

  • Participants were assigned to either an experimental group (8 sessions of SMT) or a control group (8 sessions of general memory exercises).
  • Neuropsychological assessments were performed at baseline, post-treatment, and 5 weeks later.

    • Main Results:

    • The SMT group showed significant improvements in learning abilities compared to controls, particularly in participants with moderate-severe learning deficits (P<0.01).
    • 88% of moderately-severely impaired participants in the SMT group demonstrated enhanced learning.
    • Self-reported memory improvements were significant in the SMT group but not in the control group (P<0.01).

    Conclusions:

    • Memory rehabilitation using SMT, which incorporates context and imagery, is an effective treatment for learning and memory deficits in MS.
    • Patient selection is crucial, with individuals exhibiting moderate-to-severe impairments benefiting most from SMT.
    • SMT offers a promising avenue for cognitive rehabilitation in multiple sclerosis patients.