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  1. Home
  3. Evidence-based Cognitive Rehabilitation For Persons With Multiple Sclerosis: An Updated Systematic Review 2016 To 2024.
  1. Home
  3. Evidence-based Cognitive Rehabilitation For Persons With Multiple Sclerosis: An Updated Systematic Review 2016 To 2024.

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Evidence-Based Cognitive Rehabilitation for Persons With Multiple Sclerosis: An Updated Systematic Review 2016 to

Yael Goverover1, Silvana L Costa2, Victor W Mark3

  • 1Department of Occupational Therapy, New York University, New York, NY; Center for Neuropsychology and Neuroscience Research, Kessler Foundation, West Orange, NJ.

Archives of Physical Medicine and Rehabilitation
|May 26, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Cognitive rehabilitation (CR) for Multiple Sclerosis (MS) shows increasing research, but more high-quality studies are needed. Future research should focus on long-term effectiveness and real-world functional improvements for persons with MS.

Keywords:
Cognitive trainingEvidence-based practiceMultiple sclerosis, RehabilitationTreatment efficacy

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Cognitive Science

Background:

  • Cognitive impairment is a significant challenge for persons with Multiple Sclerosis (PwMS).
  • Cognitive rehabilitation (CR) aims to improve cognitive functions affected by MS.
  • Prior reviews have synthesized evidence, necessitating an updated synthesis of recent research.

Purpose of the Study:

  • To systematically review and synthesize evidence on CR interventions for PwMS published from 2016 to 2024.
  • To identify effective CR treatments and guide future research directions.
  • To extend prior reviews by incorporating the latest findings in the field.

Main Methods:

  • Comprehensive database searches (PubMed, PsycINFO, CINAHL, Embase, Global Health) using relevant keywords and MeSH terms.
  • Screening of over 10,000 articles, with 67 studies providing original data after detailed review.
  • Data extraction on study design, participant characteristics, interventions, cognitive domains, and outcomes, with evidence levels determined by American Academy of Neurology criteria.

    • Main Results:

    • The review included 7 class I, 30 class II, 18 class III, and 12 class IV studies.
    • Five interventions supported a practice standard, five supported practice guidelines, and 17 practice options received support.
    • Evidence synthesis indicates progress but highlights the need for more rigorous research designs.

    Conclusions:

    • Research in CR for MS continues to grow.
    • Further methodologically rigorous studies, particularly Class I evidence, are needed to support specific treatment strategies.
    • Longitudinal research is crucial to understand long-term effectiveness and the translation of CR gains to functional, real-world activities for PwMS.