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[Castleman disease in the pelvic cavity]
Yoichi Kakuta1, Natsuki Takaha, Kazuo Nishimura
1The Department of Urology, Osaka University Graduate School of Medicine.
Hinyokika Kiyo. Acta Urologica Japonica
|March 1, 2005
Summary
This report details a rare pelvic Castleman disease case in a 36-year-old man. Surgical removal of the plasma cell type mass resolved fever and normalized inflammatory markers.
Area of Science:
- Oncology
- Pathology
Background:
- Castleman disease is a rare lymphoproliferative disorder.
- It most commonly affects the thoracic lymph nodes.
- Pelvic Castleman disease is exceptionally rare, with few documented cases.
Observation:
- A 36-year-old male presented with fever and elevated inflammatory markers (CRP and IL-6).
- Imaging revealed a calcified solid mass in the pelvic cavity.
- The mass was surgically excised and measured 75 x 45 x 30 mm.
Findings:
- Histological examination confirmed the plasma cell type of Castleman disease.
- Post-operative normalization of fever, CRP, and IL-6 levels was observed.
- One-year follow-up showed no evidence of disease recurrence.
Implications:
- This case expands the understanding of Castleman disease presentation in rare locations.
- Highlights the effectiveness of surgical resection for pelvic Castleman disease.
- Emphasizes the role of IL-6 in Castleman disease pathogenesis and as a biomarker.
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