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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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Published on: April 21, 2015

Infliximab induced T lymphocyte apoptosis in Crohn's disease

Jan van den Brande1, Daan W Hommes, Maikel P Peppelenbosch

  • 1Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands. J.vandenbrande@amc.uva.nl

The Journal of Rheumatology. Supplement
|March 3, 2005
PubMed

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract of unknown origin. Therapies include immune modulating agents, biological therapies, and surgery. The activity and efficacy of the anti-tumor necrosis factor (TNF) therapies infliximab and etanercept have proved to be different: infliximab is effective to induce and maintain remission in refractory CD, while etanercept is not. This brief review considers the question of whether this disparity can be explained by the different structure of the proteins, their different binding affinities, or the subsequent effects on T lymphocytes.

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