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Updated: Aug 18, 2026

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
Published on: August 29, 2016
Preliminary results of three-dimensional reconstruction of previously imaged prostates
I A Sesterhenn1, F K Mostofi, R R Mattrey
1Department of Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000.
Abstract:
In patients with biopsy proven prostate cancer, preoperative transrectal magnetic resonance imaging (MRI) and ultrasound were performed, followed by total prostatectomy. Generally, the findings with MRI correlated well with the histopathologic findings, including infiltration of and extension through the capsule into periprostatic tissue and the seminal vesicles. False negative results with MRI included centrally located tumors and small tumors. False positive results with MRI included lobular atrophy, cystic hyperplasia, cystic atrophy, florid glandular hyperplasia and scars with chronic inflammation.

