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Precise quantification of pressure flow waveforms of a pulsatile ventricular assist device
Akif Undar1, Conrad M Zapanta, John D Reibson
1Department of Pediatrics, Penn State College of Medicine, Penn State Children's Hospital, Penn State Milton S. Hershey Medical Center, 500 University Drive, P.O. Box 850, Hershey, PA 17033-0850, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|March 5, 2005
Summary
Quantifying pulsatile flow is crucial for assessing perfusion. This study introduces energy equivalent pressure (EEP) and surplus hemodynamic energy (SHE) to measure pulsatility, finding a pulsatile VAD system generates near physiologic energy levels.
Area of Science:
- Cardiovascular Engineering
- Biomedical Engineering
- Hemodynamics
Background:
- Accurate quantification of pulsatile flow is essential for evaluating perfusion modes.
- Pulsatile flow generation relies on energy gradients, necessitating robust measurement methods.
- Existing methods struggle to compare different perfusion modes effectively.
Purpose of the Study:
- To quantify pressure-flow waveforms using energy equivalent pressure (EEP) and surplus hemodynamic energy (SHE).
- To assess hemodynamic energy levels generated by a pulsatile Ventricle Assist Device (VAD).
- To establish a valid comparison between perfusion modes during chronic support.
Main Methods:
- Utilized a 70 cc Pierce-Donachy pneumatic pulsatile VAD in an adult mock loop.
- Maintained constant pump flow rate (5 L/min) at varying pump rates (70-80 bpm) and mean aortic pressures (MAP: 80-100 mm Hg).
- Calculated EEP and SHE using established formulas, adjusting pump parameters and systemic resistance.
Main Results:
- EEP levels ranged from 88.3 to 107.4 mm Hg, showing a percentage change from MAP between 7.4% and 10.4%.
- Surplus hemodynamic energy (SHE) values were consistently high, indicating significant energy generation.
- Results remained consistent across different pump rates, suggesting device reliability.
Conclusions:
- The developed EEP and SHE formulas effectively quantify pulsatility for meaningful comparisons.
- The tested pulsatile VAD system generates hemodynamic energy levels comparable to physiologic conditions.
- This quantification method aids in assessing the importance of pulsatile perfusion in VAD support.