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Updated: Jul 14, 2026
10:55
Rescue of Recombinant Newcastle Disease Virus from cDNA
Published on: October 12, 2013
[Virus-induced expression of type I interferon genes]
Mitsutoshi Yoneyama1, Takashi Fujita
1Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613 Japan. yoneyama@rinshoken.or.jp
Uirusu
|March 5, 2005
Summary
Retinoic acid inducible gene-I (RIG-I) recognizes viral double-stranded RNA, triggering antiviral defenses. This review details RIG-I
Area of Science:
- Immunology
- Virology
- Molecular Biology
Background:
- Intracellular double-stranded (ds) RNA is a key viral replication indicator.
- Host pattern recognition receptors detect viral dsRNA to initiate antiviral responses.
- The retinoic acid inducible gene-I (RIG-I) protein is crucial for dsRNA sensing.
Purpose of the Study:
- To review the critical role of RIG-I in antiviral innate immunity.
- To elucidate the mechanisms by which RIG-I detects viral dsRNA and initiates signaling.
Main Methods:
- Review of existing literature on RIG-I function and antiviral pathways.
- Analysis of RIG-I structure-function relationships, including its helicase and CARD domains.
Main Results:
- RIG-I, a DExD/H box RNA helicase, recognizes viral dsRNA via its helicase domain.
- Intact ATPase activity is essential for RIG-I's dsRNA binding and recognition.
- The caspase recruitment domain (CARD) of RIG-I transmits downstream signaling cascades.
Conclusions:
- RIG-I acts as a central sensor for viral dsRNA in innate immunity.
- RIG-I activation leads to the induction of antiviral genes, including type I interferons.
- Understanding RIG-I function is key to developing novel antiviral therapies.
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