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Topical delivery of celecoxib using microemulsion
Natesan Subramanian1, Saroj Kumar Ghosal, Satya Priya Moulik
1Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India.
Acta Poloniae Pharmaceutica
|March 8, 2005
Summary
Microemulsions effectively deliver celecoxib for treating UV B-induced skin cancer. Optimized formulations enhance celecoxib skin permeation and exhibit significant anti-inflammatory effects.
Area of Science:
- Dermatology
- Pharmaceutics
- Nanotechnology
Background:
- Ultraviolet B (UV B) radiation is a known carcinogen causing skin damage.
- Celecoxib, a non-steroidal anti-inflammatory drug (NSAID), has potential anti-cancer properties.
- Effective topical delivery systems are needed to enhance celecoxib's efficacy for skin conditions.
Purpose of the Study:
- To investigate microemulsions as a vehicle for topical celecoxib delivery.
- To optimize microemulsion formulations for enhanced skin permeation.
- To evaluate the anti-inflammatory and anti-cancer potential of celecoxib microemulsions.
Main Methods:
- Construction of pseudoternary phase diagrams to identify microemulsion regions.
- Evaluation of celecoxib skin permeation using excised rat skin.
- Assessment of topical anti-inflammatory activity via the arachidonic acid-induced ear edema model.
Main Results:
- Microemulsion formulations were successfully developed.
- Formulation E (3% celecoxib, 22% oil/co-surfactant blend, 30% polysorbate 80, water) showed enhanced celecoxib permeation.
- Formulation E demonstrated significant topical anti-inflammatory activity.
Conclusions:
- Microemulsions are promising vehicles for topical celecoxib delivery.
- Optimized microemulsions can improve celecoxib skin permeation and anti-inflammatory effects.
- These formulations hold potential for treating UV B-induced skin cancer.