Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temperature compensation in circadian clock models.

Gen Kurosawa1, Yoh Iwasa

  • 1Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka-shi, Fukuoka 812-8581, Japan. kurosawa@bio-math10.biology.kyushu-u.ac.jp

Journal of Theoretical Biology
|March 8, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frequency-modulated timer regulates torpor-arousal cycles during hibernation in distinct small mammalian hibernators.

Npj biological timing and sleep·2026
Same author

Is Thymic Involution Truly a Deterioration or an Adaptation?

Bulletin of mathematical biology·2026
Same author

Human papillomavirus driving cervical cancer: A mathematical model with persistent infection, cancer progression, and spontaneous remission.

Journal of theoretical biology·2025
Same author

Waveform distortion for temperature compensation and synchronization in circadian rhythms: An approach based on the renormalization group method.

PLoS computational biology·2025
Same author

Branching architecture affects genetic diversity within an individual tree.

Journal of theoretical biology·2025
Same author

Age-dependence of food allergy due to decreased supply of naïve T cells.

Journal of theoretical biology·2025

Organisms

Area of Science:

  • Biochemistry
  • Chronobiology
  • Systems Biology

Background:

  • Circadian clocks exhibit temperature compensation, maintaining a stable period despite ambient temperature fluctuations.
  • Understanding the molecular mechanisms underlying this temperature compensation is crucial for explaining biological rhythm stability.

Purpose of the Study:

  • To investigate the impact of temperature on the period of circadian clock models.
  • To identify key molecular parameters and reaction properties that contribute to temperature compensation in circadian rhythms.

Main Methods:

  • Analysis of biochemical network models for circadian rhythms.
  • Mathematical modeling of N-variable and PER-TIM double oscillator systems.
  • Simulation of parameter changes and their effects on the clock's period.

Related Experiment Videos

Main Results:

  • Enhancing all reaction rates uniformly shortens the circadian period.
  • Increased protein degradation or gene transcription rates lengthen the period, indicating positive elasticity.
  • Temperature compensation is maintained under specific conditions, including saturated degradation reactions and moderate cooperativity in transcription inhibition.

Conclusions:

  • The stability of circadian clock periods across temperatures is explained by specific kinetic properties within the underlying biochemical network.
  • Protein degradation rates and transcription rates play critical roles in temperature compensation.
  • Mechanisms like temperature-sensitive protein degradation or alternative splicing, as observed in Drosophila, can facilitate robust circadian rhythms.