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Updated: Aug 19, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Adipose tissue is a regulated source of interleukin-10
Cristiana E Juge-Aubry1, Emmanuel Somm, Agnès Pernin
1Laboratory of Molecular Endocrinology, Department of Medicine, Geneva Medical School, rue Michel Servet 1, CH-1211 Geneva 4, Switzerland.
Abstract:
White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase).
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