Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional MRI using molecular imaging agents.

Alan Jasanoff1

  • 1Department of Nuclear Science & Engineering, Massachusetts Institute of Technology, NW14-2213, 150 Albany Street, Cambridge, MA 02139, USA. jasanoff@mit.edu

Trends in Neurosciences
|March 8, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liposomal nanoprobes actuated by engineered water channels for sensitive detection of molecular targets by MRI.

Nature biomedical engineering·2026
Same author

Quantitative comparison of methods for widespread delivery of small molecules across the blood-brain barrier.

Communications biology·2026
Same author

A molecular probe for detecting cholinesterase activity in MRI.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Peripheral contributions to resting state brain dynamics.

Nature communications·2024
Same author

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo.

Advanced materials (Deerfield Beach, Fla.)·2024
Same author

Magnetic Detection of Neural Activity by Nanocoil Transducers.

Nano letters·2024
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
See all related articles

New molecular imaging agents for magnetic resonance imaging (MRI) offer cellular-level insights into neural function. These advanced MRI probes promise faster, high-resolution brain imaging, potentially replacing traditional methods.

Area of Science:

  • Neuroimaging
  • Molecular Imaging
  • Biomedical Engineering

Background:

  • Magnetic resonance imaging (MRI) is increasingly used for cellular-level neural function probes.
  • In vivo labeling strategies allow tracking of brain plasticity and cellular changes over time.
  • Current functional MRI (fMRI) relies on hemodynamics, limiting temporal and spatial resolution.

Purpose of the Study:

  • To explore the development of molecular imaging agents for high-temporal-resolution functional MRI (fMRI).
  • To investigate novel MRI sensors as an alternative to conventional hemodynamics-based fMRI approaches.
  • To enhance MRI's capability for mechanistic investigation of neural systems.

Main Methods:

  • Development of MRI sensors based on defined principles for molecular fMRI.

Related Experiment Videos

  • Application of engineered sensors to detect cellular-level correlates of neuronal activity.
  • Advancements in imaging-agent delivery methods and high-resolution neuroimaging model systems.

    • Main Results:

    • Established principles for constructing "molecular fMRI" imaging agents.
    • Demonstrated potential for combining MRI's noninvasiveness with high spatial (microns) and temporal (≤100ms) resolution.
    • Showcased novel molecular imaging strategies for mechanistic neuroscience.

    Conclusions:

    • Molecular imaging agents hold promise for functional neuroimaging with unprecedented resolution.
    • These novel strategies significantly potentiate MRI as a tool for understanding neural systems.
    • Future developments may offer a powerful alternative to current hemodynamics-based functional imaging techniques.