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Updated: Aug 19, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Toxic neuropathies
Patrick M Grogan1, Jonathan S Katz
1Department of Neurology, Wilford Hall Medical Center, San Antonio, TX 78236, USA. patrick.grogan@lackland.af.mil
Abstract:
Many substances, organic and manufactured, may induce peripheral nerve damage when exposed to them. The expected clinical phenotype is of a distal, sensory or sensorimotor polyneuropathy, often painful, with axonal characteristics on electrodiagnostic and histopathologic analysis. Treatment is limited; often, the only effective management is supportive care and avoidance from or removal of the offending toxin. Fortunately, the majority of toxic neuropathies are self-limited and improves gradually after toxin elimination.
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