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[Prevalence of anti-mumps IgG antibodies in a pediatric population]
J Suárez1, M R Castañeda, C Gutiérrez
1Unidad de Microbiología e Inmunología, Facultad de Veterinaria, Universidad de León.
Insights
Most children aged 2-14 in Spain have mumps antibodies, indicating successful vaccination. However, a significant portion of vaccinated children remain susceptible, highlighting the need for ongoing monitoring of mumps immunity.
Area of Science:
- Immunology
- Pediatrics
- Public Health
Context:
- Mumps virus IgG antibody prevalence was assessed in a Spanish pediatric population.
- Understanding immunity is crucial for public health strategies and vaccine efficacy evaluation.
Purpose:
- To determine the prevalence of IgG antibodies against mumps virus in children aged 2-14 years.
- To evaluate the impact of vaccination on mumps immunity within this age group.
Summary:
- A study of 800 children in Spain found 76.87% had positive mumps virus IgG antibodies.
- 27.13% of children were susceptible to mumps.
- Among vaccinated children, 25.8% lacked detectable antibodies.
Impact:
- High vaccination coverage has significantly altered the immune status of children, with most having antibodies generated by the mumps vaccine.
- Findings suggest potential gaps in vaccine-induced immunity requiring further investigation.
Background:
To assess the prevalence of IgG antibodies against mumps virus, using an enzyme-linked immune assay, among a pediatric population aged from 2 to 14 years.
Method:
Using a systematic sampling technique among rural and urban pediatric population in a sanitary Spanish area (Leon, Spain) we enrolled 800 children in the study. In all cases the vaccination status, prior history of mumps and also data regarding the place where the vaccination took place were recorded. The presence or absence of IgG antibodies against mumps virus was determined using a standard commercially-available technique (EIA Stat IgG Mumps).
Results:
Of all children enrolled in the study, a 76.87% +/- 2.92% showed a positive antibody response against mumps virus. The percentage of susceptible children to mumps virus was therefore deemed to be 27.13% +/- 2.9%. A total of 100 children (25.8%) of all 387 who were previously vaccinated did not show presence of antibodies against mumps.
Conclusions:
In our study, the immunity pattern did not showed statistical positive correlation with all variables assessed: sex, place where the vaccine was given, residence (rural/urban). The high rates of vaccination coverage achieved among children aged 2 to 14 had induced a major change in the immune status, a 71.20% of children had IgG antibodies against mumps, that in nearly all cases had been generated by the use of the mumps vaccine.