Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone tissue induction, using a COLLOSS-filled titanium fibre mesh-scaffolding material.

X Frank Walboomers1, John A Jansen

  • 1Department of Periodontology and Biomaterials, University Medical Center, P.O. Box 9101, THK 117 PB, 6500 HB Nijmegen, The Netherlands.

Biomaterials
|March 15, 2005
PubMed
Summary

COLLOSS, a bovine extracellular matrix product, demonstrated bone-inducing properties when loaded into titanium implants in a rat study. Further research in larger animals is needed to confirm its osteo-inductive efficacy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calcium Phosphate Cements: From the 1980s to the 2020s.

Tissue engineering. Part C, Methods·2025
Same author

Editorial: Calcium Phosphate Ceramics: The Living Bridge Between Biology and Biomaterials.

Tissue engineering. Part C, Methods·2025
Same author

Editorial: The Role of Artificial Intelligence in Biomaterials Development: A Paradigm Shift.

Tissue engineering. Part C, Methods·2025
Same author

Editorial: The Need for Validation of Organoids in Regenerative Medicine Research.

Tissue engineering. Part C, Methods·2025
Same author

Compositional Variations in Calcium Phosphate Cement and Poly(Lactic-Co-Glycolic-Acid) Porogens Do Not Affect the Orthotopic Performance of Calcium Phosphate Cement/Poly(Lactic-Co-Glycolic-Acid) Cements.

Journal of biomedical materials research. Part A·2024
Same author

Biological Processes in Gingival Tissue Integration Around Dental Implants.

Tissue engineering. Part B, Reviews·2024

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Scaffold materials are crucial for bone tissue engineering, often enhanced with bone morphogenetic proteins (BMPs).
  • COLLOSS, a bovine extracellular matrix product, naturally contains BMPs and was investigated for its bone-inducing potential.

Purpose of the Study:

  • To evaluate the osteo-inductive properties of COLLOSS when incorporated into titanium fiber mesh implants.
  • To assess bone-like tissue formation in vivo using a subcutaneous rat model.

Main Methods:

  • Hollow cylindrical titanium fiber mesh implants (10mm length, 3mm inner diameter, 5mm outer diameter) were loaded with 20 mg of COLLOSS.
  • Implants, with and without COLLOSS, were subcutaneously implanted into Wistar rats (n=6 per group).

Related Experiment Videos

  • Histological analysis was performed at 2, 8, and 12 weeks post-implantation.

    • Main Results:

    • Histology revealed a fibrous capsule around all implants.
    • At 2 weeks, COLLOSS material degraded with no bone formation.
    • Bone and bone marrow-like tissue formed in 2/6 implants at 8 weeks and 5/6 at 12 weeks, occupying ~15% of the implant space.
    • Control implants showed only connective tissue ingrowth.

    Conclusions:

    • COLLOSS, when loaded into titanium fiber mesh tubes, exhibits bone-inducing capabilities.
    • The study supports the osteo-inductive potential of COLLOSS in a preclinical setting.
    • Further validation in large animal models is recommended to confirm efficacy.