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Dermal capillary clearance: physiology and modeling.

K Kretsos1, G B Kasting

  • 1University at Buffalo, State University of New York, Department of Chemical and Biological Engineering, Buffalo, NY, USA. Kosmas.Kretsos@uc.edu

Skin Pharmacology and Physiology
|March 16, 2005
PubMed
Summary

This review analyzes how substances penetrate skin layers and enter circulation. It quantizes dermal microcirculatory physiology and reviews computational models for dermal clearance.

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Area of Science:

  • Dermal transport and microcirculation
  • Pharmacokinetics and drug delivery

Background:

  • Substances applied topically can enter systemic circulation via dermal absorption.
  • Understanding dermal clearance is crucial for topical drug efficacy and safety.

Purpose of the Study:

  • To analyze the dermal clearance/exchange process in depth.
  • To provide a quantitative, engineering-based framework for dermal microcirculatory physiology.
  • To review and compare computational models of dermal clearance.

Main Methods:

  • Adopting an engineering perspective to quantify dermal microcirculatory physiology.
  • Developing a theoretical framework for the physics of transport processes.
  • Comparative review of existing computational clearance models.

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  • Reporting experimental data relevant to modeling.

    • Main Results:

    • Dermal absorption involves interstitial transport, microvascular barrier permeability, and circulatory removal.
    • Quantitative analysis provides a framework for understanding dermal clearance.
    • Computational models offer varying approaches to simulating dermal transport.

    Conclusions:

    • A quantitative understanding of dermal clearance is essential for predicting substance behavior in the skin.
    • The review provides a framework for integrating physiological data with computational modeling.
    • Further research should focus on refining models with experimental data for improved predictions.