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[Acute encephalic manifestations in Senegalese children with sickle cell disease]

I Diagne1, N R Diagne-Guèye, L Fall

  • 1Chaire de Pédiatrie de l'Université Cheikh Anta Diop de Dakar - Hôpital d'Enfants Albert Royer - CHU Dde Fann- BP 5035 Dakar (Sénégal).

Dakar Medical
|March 19, 2005
PubMed

Insights

Neurologic events like stroke complicate sickle cell disease (SCD) in children. In Senegal, stroke incidence was low, but preventing recurrence poses challenges due to limited transfusion program access.

Area of Science:

  • Neurology
  • Hematology
  • Pediatrics

Context:

  • Sickle cell disease (SCD) management is complex, with neurologic events like stroke being significant complications.
  • Understanding the prevalence and characteristics of acute encephalic manifestations (AEM) in pediatric SCD is crucial for effective care.
  • This study focuses on a cohort of children and adolescents with SCD in Dakar, Senegal, over a ten-year period.

Purpose:

  • To retrospectively analyze cases of acute encephalic manifestations (AEM), particularly stroke, in children and adolescents with sickle cell disease (SCD).
  • To determine the prevalence of AEM and stroke in this cohort and identify any distinctive clinical or biological features.
  • To assess recurrence rates and discuss the challenges in implementing preventive strategies like transfusion programs in resource-limited settings.

Summary:

  • Seven patients (1.5% of SCD cohort) presented with AEM, primarily stroke, all having sickle cell anemia (SCA).
  • No specific clinical or biological markers distinguished SCA patients with stroke from those without.
  • Recurrence was observed, and the study highlights the difficulty in applying transfusion programs for prevention, suggesting hydroxyurea as a potential alternative.

Impact:

  • Stroke is a rare but significant complication of pediatric SCD in Senegal, posing challenges for preventive care.
  • The findings underscore the need for alternative strategies, such as hydroxyurea, for managing recurrent stroke in resource-limited settings.
  • This research contributes to understanding SCD-related neurological complications in African populations and informs clinical management guidelines.

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