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[FGF-23 on hypophosphatemic rickets/osteomalacia]
1Metabolism, Endocrinology, and molecular Medicine Osaka City University Graduate School of Medicine.
Clinical Calcium
|March 19, 2005
Summary
Fibroblast growth factor 23 (FGF-23) is now recognized as the cause of hypophosphatemic rickets, a condition formerly called phosphatonin. This research reviews the development of X-linked hypophosphatemic rickets, autosomal dominant hypophosphatemic rickets, and oncogenic osteomalacia.
Area of Science:
- Endocrinology and Bone Metabolism
- Genetics and Molecular Biology
Context:
- Fibroblast growth factor 23 (FGF-23) is a key hormone regulating phosphate and vitamin D metabolism.
- Previously, the specific molecular cause of certain hypophosphatemic rickets was unknown, with FGF-23 being termed 'phosphatonin'.
Purpose:
- To elucidate the role of FGF-23 in the pathogenesis of hypophosphatemic rickets.
- To discuss the mechanisms underlying X-linked hypophosphatemic rickets (XLH), autosomal dominant hypophosphatemic rickets (ADHR), and oncogenic osteomalacia (OOM).
Summary:
- Recent findings identify fibroblast growth factor 23 (FGF-23) as the causative agent in various forms of hypophosphatemic rickets.
- The study details the pathogenesis of XLH, ADHR, and OOM, linking them to FGF-23 dysregulation.
Impact:
- Establishes FGF-23 as a central factor in hypophosphatemic bone diseases.
- Provides a foundation for understanding and potentially treating these rare genetic disorders.
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