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Updated: Aug 19, 2026

Subcellular Imaging of Neuronal Calcium Handling In Vivo
Published on: March 17, 2023
[Effect of extracellular Ca2+ on neuronal function]
1Tokyo Metropolitan Institute for Neuroscience, Department of Molecular Neurophysiology.
Abstract:
Metabotropic glutamate receptors (mGluR) are well known to have a significance for the plastic change of synaptic neurotransmission. We observed that mGluR can be activated not only by glutamate but also by extracellular Ca(2+) of physiological concentration. Our observation suggests that extracellular Ca(2+) plays a critical role for the neuronal function, not only by serving as a source to elevate intracellular Ca(2+) concentration by entering through various channels, but also by activating metabotropic glutamate receptors as a ligand.
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