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Antiangiogenesis by chemotherapeutic agents
Domenico Ribatti1, Angelo Vacca, Francesca Merchionne
1Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. ribatti@anatomia.uniba.it
Mini Reviews in Medicinal Chemistry
|March 22, 2005
Summary
Chemotherapy agents can target tumor blood vessel cells, offering a new strategy to treat incurable tumors. This review explores their antiangiogenic effects, alone or combined with other inhibitors.
Area of Science:
- Oncology
- Vascular Biology
- Pharmacology
Background:
- Current cancer treatments often fail because they solely target tumor cells.
- Intratumoral endothelial cells are crucial for tumor growth and are sensitive to chemotherapy.
- Targeting tumor vasculature presents a promising therapeutic avenue.
Purpose of the Study:
- To review the literature on the antiangiogenic effects of chemotherapeutic agents.
- To evaluate these effects when agents are used alone or in combination therapy.
- To highlight the potential of targeting tumor angiogenesis.
Main Methods:
- Comprehensive literature search of studies on chemotherapeutic agents and angiogenesis.
- Analysis of data regarding the antiangiogenic properties of various chemotherapeutic drugs.
- Review of combination therapies involving chemotherapy and angiogenesis inhibitors.
Main Results:
- Chemotherapeutic agents demonstrate significant antiangiogenic effects by targeting intratumoral endothelial cells.
- These agents exhibit cytotoxicity towards rapidly proliferating endothelial cells.
- Combination therapies may enhance antiangiogenic efficacy.
Conclusions:
- Chemotherapeutic agents possess inherent antiangiogenic properties.
- Targeting tumor vasculature with chemotherapy offers a viable strategy for treating otherwise incurable tumors.
- Further research into combination therapies is warranted to optimize treatment outcomes.