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Updated: Aug 18, 2026

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies
Published on: January 3, 2018
Design and synthesis of asymmetric acyclic phospholipid bolaamphiphiles
Toshitsugu Kai1, Xue-Long Sun, Keith M Faucher
1Department of Surgery, Emory University School of Medicine, Integrated Microscopy & Microanalytical Facility, Emory University, Atlanta, Georgia 30322, USA.
Abstract:
[structure: see text] A synthetic route was devised for the generation of asymmetric lipid bolaamphiphiles through the sequential esterification of an alkyldioic acid, bearing distinct terminal protecting groups, with propanylamine and lyso-phosphatidylcholine headgroups. Bolaamphiphile self-assembly was investigated in solvent mixes of varying polarity by nuclear magnetic resonance (NMR) and Fourier transform-infrared (FT-IR) spectroscopy, as well as in water by cryo-high-resolution scanning electron microscopy (cryo-HRSEM). We anticipate that asymmetric lipid bolaamphiphiles will provide facile building blocks for engineering a variety of unique membrane-mimetic structures.
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