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Related Experiment Videos

Measuring EGJ opening patterns using high resolution intraluminal impedance.

J E Pandolfino1, G Shi, Q Zhang

  • 1Department of Medicine, Northwestern University, The Feinberg School of Medicine, 676 N. St Clair Street, Suite 1400, Chicago, IL 60611, USA. j-pandolfino@northwestern.edu

Neurogastroenterology and Motility
|March 25, 2005
PubMed
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Impedance monitoring can now track esophagogastric junction (EGJ) opening during swallowing and transient relaxations. This method distinguishes opening from relaxation and identifies contents, aiding in understanding EGJ function.

Area of Science:

  • Gastroenterology
  • Physiology
  • Medical Engineering

Background:

  • The esophagogastric junction (EGJ) controls reflux. Understanding its opening dynamics during relaxation is crucial for diagnosing motility disorders.
  • Deglutitive LES relaxation (dLESR) and transient LES relaxation (tLESR) are key physiological events affecting EGJ function.

Purpose of the Study:

  • To adapt impedance methodology for studying EGJ sphincter opening.
  • To compare EGJ opening patterns during dLESR and tLESR in healthy subjects.

Main Methods:

  • Utilized a novel 12-lumen combined impedance/manometry catheter with a sleeve sensor and impedance rings.
  • Analyzed air infusion data tracings and isocontour plots to assess EGJ opening characteristics.

Main Results:

Related Experiment Videos

  • dLESR showed a top-to-bottom opening pattern, primarily with liquid boluses.
  • tLESR exhibited a bottom-to-top opening pattern, also frequently involving liquid.
  • Impedance monitoring successfully identified sphincter opening and determined luminal contents.

Conclusions:

  • Impedance methodology is adaptable for studying EGJ sphincter opening.
  • This technique can differentiate sphincter opening from relaxation.
  • It provides insights into luminal contents during EGJ opening events.