Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecularly sensitive optical coherence tomography.

Jeremy S Bredfeldt1, Claudio Vinegoni, Daniel L Marks

  • 1Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA.

Optics Letters
|March 26, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual activation of MC3R and MC4R drives weight loss and reduces food intake in male primates with obesity.

Nature communications·2026
Same author

The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives.

Frontiers in endocrinology·2026
Same author

Endogenous targeting lipid nanoparticles for systemic mRNA delivery to lung cancer tumors.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Sympathetic nerve-fibroblast crosstalk drives nerve injury, fibroblast activation, and matrix remodeling in pancreatic cancer.

JCI insight·2026
Same author

Clinical Validation and Prospective Deployment of an Automated Deep Learning-Based Coronary Segmentation and Cardiac Toxicity Risk Prediction System.

ArXiv·2025
Same author

Targeting cancer-associated fibroblasts for real-time intraoperative tumor identification with a spray-on fluorescent probe.

Science advances·2025
Same journal

Gaussian-modulated continuous-variable quantum key distribution over 60 km fiber using an integrated silicon photonic receiver.

Optics letters·2026
Same journal

E2E-OCT: end-to-end joint learning model using optical coherence tomography images for vocal cord leukoplakia diagnosis.

Optics letters·2026
Same journal

Holographic generation of panoramic 3D scenes by concave ellipsoidal mirror reflection.

Optics letters·2026
Same journal

Dual-pilot phase recovery with pair-wise maximum-ratio combining for coherent PONs.

Optics letters·2026
Same journal

Mapping the whispering gallery modes of a CaF<sub>2</sub> disk resonator with half-tapered fibers to estimate the fundamental mode volume.

Optics letters·2026
Same journal

Quantitative estimation of deep-subwavelength scale via dark-field scattering axial energy concentration decay profiles.

Optics letters·2026
See all related articles

Optical coherence tomography (OCT) now offers molecular contrast using coherent anti-Stokes Raman scattering (CARS) for enhanced sensitivity. This new method enables chemical selectivity and deep tissue imaging for biological applications.

Area of Science:

  • Biomedical Optics
  • Spectroscopy
  • Medical Imaging

Background:

  • Optical coherence tomography (OCT) is a powerful imaging technique but lacks molecular specificity.
  • Coherent anti-Stokes Raman scattering (CARS) provides chemical contrast but is challenging to integrate with depth-resolved imaging.
  • Developing molecularly sensitive OCT is crucial for advanced biological tissue analysis.

Purpose of the Study:

  • To demonstrate molecular contrast in OCT using CARS.
  • To investigate the feasibility of interferometric measurement of CARS signals for imaging.
  • To assess the potential of this hybrid technique for biological tissue imaging.

Main Methods:

  • Utilized femtosecond laser pulses focused by a low-numerical-aperture lens to generate CARS photons.

Related Experiment Videos

  • Employed interferometric measurement of the backreflected CARS signal.
  • Evaluated CARS generation and detection over a significant depth of field (≥600 micrometers).

    • Main Results:

    • Successfully demonstrated molecular contrast in OCT by integrating CARS.
    • Achieved interferometric measurement of the CARS signal.
    • Confirmed CARS generation and measurement within the depth of field of a low-NA objective.

    Conclusions:

    • The combination of CARS and OCT provides molecular sensitivity for optical imaging.
    • This technique offers chemical selectivity alongside OCT's imaging capabilities.
    • Potential applications include molecular contrast imaging in biological tissues.